Restylane® is a brand name for hyaluronic acid, which is a relatively modern development in the field of cosmetic treatments. Hyaluronic acid (HA) is a naturally-occurring substance present in the body, particularly in fluid around the eyes and joints, that acts as a cushion and lubricant. HA is hydrophilic–meaning it draws water to itself–which helps keep the skin around it moist and plump.

REFYNE and DEFYNE are hyaluronic acid-based gels that are specifically designed to be extremely flexible. They were developed by Restylane® in response to feedback from potential customers whose central concern was retaining a ‘natural’ look after cosmetic treatment. There are hyaluronic acid fillers on the market already, but only REFYNE and DEFYNE contain the patented XpressHAn formulation for the best elasticity.

REFYNE and DEFYNE are two very similar products from Restylane® with only a few distinctions. REFYNE is approved for treatment of moderate to severe facial wrinkles, including nasolabial folds and marionette lines, a.k.a. laugh lines. DEFYNE, on the other hand, is approved for the same treatment but is formulated to provide more support for deep lines and wrinkles.